Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | MVD | P53602 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9640252 | 1.00 | KDM1A (0.35) | KDM1ATSHREPHX2POLBHSD17B10 | |
| SCHEMBL5638161 | 0.88 | TSHR (0.40) | KDM1ATSHRPOLBHSD17B10MGAM | |
| SCHEMBL19434543 | 0.85 | TSHR (0.39) | KDM1ATSHRHSD17B10MGAMGAA | |
| SCHEMBL2474164 | 0.82 | CA2 (0.35) | HSD17B10MVDCA2 | |
| SCHEMBL9640732 | 0.82 | MVD (0.47) | TSHRPOLBHSD17B10MVDALDH1A1 | |
| SCHEMBL19434602 | 0.81 | KDM4E (0.35) | KDM1ATSHRALDH1A1ALOX15 | |
| SCHEMBL24091754 | 0.79 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL9517329 | 0.79 | TSHR (0.48) | KDM1ATSHRPOLBHSD17B10MGAM | |
| SCHEMBL19434494 | 0.77 | DUT (0.35) | KDM1A | |
| SCHEMBL14042208 | 0.77 | ABCB11 (0.34) | KDM1ATSHREPHX2POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287042-B1 | 2-SULPHINYL-ACETYL-1,3-THIAZOLIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-16 | — | — | EP | disclosed |
| US-4849437-A | 2-sulphinyl-acetyl-1,3-thiazolidines, their preparation and pharmaceutical compositions | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-18 | — | — | US | disclosed |