Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10417059 | 0.74 | GSK3A (0.42) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL10417048 | 0.74 | GSK3A (0.42) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL7301415 | 0.72 | MEN1 (0.37) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL8590170 | 0.70 | KMT2A (0.45) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL9645295 | 0.70 | GSK3A (0.40) | GSK3AGSK3BPOLBF2ALDH1A1 | |
| SCHEMBL16291450 | 0.69 | MEN1 (0.41) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL7871541 | 0.68 | ALDH1A1 (0.34) | NPC1RAB9AKMT2APOLBHPGD | |
| SCHEMBL9645251 | 0.68 | ALDH1A1 (0.50) | NPC1RAB9AKMT2AGSK3AGSK3B | |
| SCHEMBL9645288 | 0.67 | GAA (0.44) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL669626 | 0.65 | KMT2A (0.54) | NPC1RAB9AKMT2AGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |