Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.40 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | CTSG | P08311 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RGS4 | P49798 | 1/20 | 0.37 |
| ▸ | RGS8 | P57771 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477427 | 0.80 | HPGD (0.49) | GSK3AGSK3BCTSGF2PLG | |
| SCHEMBL9645868 | 0.80 | APP (0.40) | CTSGALDH1A1 | |
| SCHEMBL9645288 | 0.73 | GAA (0.44) | CTSGCMA1ALDH1A1L3MBTL1GAA | |
| SCHEMBL7301415 | 0.72 | MEN1 (0.37) | GSK3AGSK3BALDH1A1MGLLGAA | |
| SCHEMBL25218597 | 0.70 | MEN1 (0.53) | GSK3AGSK3BCTSGF2PLG | |
| SCHEMBL9645259 | 0.70 | NPC1 (0.45) | GSK3AGSK3BF2ALDH1A1GAA | |
| SCHEMBL9396460 | 0.70 | HPGD (0.46) | GSK3AGSK3BCTSGF2PLG | |
| SCHEMBL29157597 | 0.69 | HPGD (0.45) | GSK3AGSK3BCTSGF2PLG | |
| SCHEMBL16291450 | 0.69 | MEN1 (0.41) | GSK3AGSK3BALDH1A1MGLLGAA | |
| SCHEMBL7871541 | 0.68 | ALDH1A1 (0.34) | ALDH1A1L3MBTL1MGLLGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |