Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291450 | 0.74 | MEN1 (0.41) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7871541 | 0.73 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL9645295 | 0.72 | GSK3A (0.40) | ALDH1A1GAAMGLLGSK3AGSK3B | |
| SCHEMBL9645259 | 0.72 | NPC1 (0.45) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL9645416 | 0.68 | MEN1 (0.40) | MEN1KMT2AALDH1A1GAAKDM4E | |
| SCHEMBL9645868 | 0.66 | APP (0.40) | ALDH1A1TSHRPKM | |
| SCHEMBL9645288 | 0.65 | GAA (0.44) | ALDH1A1GAASMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL22357884 | 0.64 | KMT2A (0.48) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL5170272 | 0.63 | NPC1 (0.38) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8526316 | 0.63 | MGLL (0.59) | MEN1KMT2AALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042513-B1 | DIHYDROPYRIDAZINONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1984-08-08 | — | — | EP | claimed |
| EP-0042513-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-30 | — | — | EP | claimed |
| US-5151420-A | Cardiovascular disorders | ORION CORPORATION/ORION PHARMACEUTICA (FI) | 1992-09-29 | — | — | US | disclosed |
| EP-0359439-A1 | Substituted pyridazinones | ORION-YHTYMÄ OY (FI) | 1990-03-21 | — | — | EP | disclosed |
| EP-0042513-B1 | DIHYDROPYRIDAZINONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1984-08-08 | — | — | EP | disclosed |
| US-4415571-A | HYPOTENSIVE AGENTS; THROMBOSIS; ANTICOAGULANTS; CARDIOVASCULAR DISORDDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| EP-0042513-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-30 | — | — | EP | disclosed |