Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CTSG | P08311 | 2/20 | 0.40 |
| ▸ | CMA1 | P23946 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645416 | 0.75 | MEN1 (0.40) | GAAALDH1A1L3MBTL1KDM4ECYP1A2 | |
| SCHEMBL9645280 | 0.71 | HTT (0.44) | GAAALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL9645868 | 0.70 | APP (0.40) | ALDH1A1CTSGTSHRLMNA | |
| SCHEMBL9645476 | 0.70 | LMNA (0.39) | GAAALDH1A1SMN1; SMN2KDM4ETSHR | |
| SCHEMBL9645259 | 0.67 | NPC1 (0.45) | GAAALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL10784216 | 0.66 | KMT2A (0.75) | GAAALDH1A1L3MBTL1SMN1; SMN2CYP1A2 | |
| SCHEMBL7301415 | 0.65 | MEN1 (0.37) | GAAALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL16291450 | 0.63 | MEN1 (0.41) | GAAALDH1A1SMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL7871541 | 0.62 | ALDH1A1 (0.34) | GAAALDH1A1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL11553488 | 0.61 | LMNA (0.71) | ALDH1A1SMN1; SMN2KDM4ECYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |