Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645295 | 0.80 | GSK3A (0.40) | ALDH1A1CTSG | |
| SCHEMBL9645861 | 0.70 | GRM5 (0.40) | APPTSHRGRM5ALDH1A1LMNA | |
| SCHEMBL9645288 | 0.70 | GAA (0.44) | TSHRALDH1A1CTSGLMNA | |
| SCHEMBL7301415 | 0.66 | MEN1 (0.37) | TSHRALDH1A1PKM | |
| SCHEMBL9645259 | 0.65 | NPC1 (0.45) | TSHRALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL8764825 | 0.64 | MGLL (0.59) | TSHRALDH1A1CTSGMAPK1 | |
| SCHEMBL5828559 | 0.64 | ALDH1A1 (0.49) | APPTSHRGRM5ALDH1A1CTSG | |
| SCHEMBL8062425 | 0.64 | GSK3A (0.63) | APPTSHRALDH1A1LMNAMAPK1 | |
| SCHEMBL16291450 | 0.63 | MEN1 (0.41) | TSHRALDH1A1PKMMAPK1 | |
| SCHEMBL7871541 | 0.63 | ALDH1A1 (0.34) | TSHRALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |