Sugi Predict

Sugi Predict / Compounds / SCHEMBL964570

SCHEMBL964570

SCHEMBL964570

CCOC(=O)C(NC(C)=O)C(C)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.50
▸ ALDH1A1 P00352 3/20 0.44
▸ HSD17B10 Q99714 1/20 0.42
▸ MGAM O43451 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ SI P14410 1/20 0.41
▸ MGAM2 Q2M2H8 1/20 0.41
▸ SOAT1 P35610 1/20 0.41
▸ PKM P14618 2/20 0.40
▸ THRB P10828 1/20 0.40
▸ HTT P42858 1/20 0.39
▸ MAPT P10636 2/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ CAD P27708 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.37
▸ CA12 O43570 1/20 0.37
▸ CA1 P00915 1/20 0.37
▸ CA2 P00918 1/20 0.37
▸ CA9 Q16790 1/20 0.37
▸ KMT2A Q03164 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1332017 0.91 LMNA (0.53) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL1330728 0.91 LMNA (0.53) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL1331748 0.91 LMNA (0.53) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL1332187 0.91 LMNA (0.53) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL81193 0.91 LMNA (0.53) LMNAALDH1A1HSD17B10MGAMGAA
Hydrochloric Acid SCHEMBL27898018 0.89 LMNA (0.51) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL3787404 0.89 LMNA (0.51) LMNAALDH1A1HSD17B10MGAMGAA
Acetic Acid SCHEMBL27299232 0.87 LMNA (0.50) LMNAALDH1A1HSD17B10MGAMGAA
Alcohol SCHEMBL27600744 0.87 LMNA (0.50) LMNAALDH1A1HSD17B10MGAMGAA
SCHEMBL16727820 0.85 LMNA (0.49) LMNAALDH1A1HSD17B10MGAMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3762377-B1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF UNIV CORNELL (US) 2025-08-20 — — EP disclosed
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof CORNELL UNIVERSITY (US) 2024-04-23 — — US disclosed
US-20240025856-A1 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER CISTIM LEUVEN VZW (BE) 2024-01-25 — — US disclosed
CN-106103416-B Azaspiro derivatives as TRPM8 antagonists 拉夸里亚创药株式会社 2021-03-02 — — CN disclosed
EP-3762377-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF Cook, Timothy, H. (US) 2021-01-13 — — EP disclosed
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE 2020-12-31 — — US disclosed
EP-3116858-B1 AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS RAQUALIA PHARMA INC (JP) 2020-11-11 — — EP disclosed
WO-2019173790-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND MEDICAL USES THEREOF HLA TIMOTHY (US) 2019-09-12 — — WO disclosed
US-20180339993-A1 AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS RAQUALIA PHARMA INC. (JP) 2018-11-29 — — US disclosed
EP-3256120-B1 PSORALEN DERIVATIVES AS NON-PEPTIDIC INHIBITORS OF CHYMOTRYPSIN-LIKE ACTIVITY OF THE IMMUNOPROTEASOME UNIV LJUBLJANI (SI) 2018-11-14 — — EP disclosed
WO-1999040091-A1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS AMGEN INC. (US) 1999-08-12 — — WO disclosed
EP-0646572-B1 Process for the preparation of ceramides QUEST INT (NL) 1997-07-23 — — EP disclosed
US-5525709-A Process for the preparation of ceramides UNILEVER PATENT HOLDINGS B.V. (NL) 1996-06-11 — — US disclosed
EP-0646572-A1 Process for the preparation of ceramides QUEST INTERNATIONAL B.V. (NL) 1995-04-05 — — EP disclosed
US-5322964-A Process for the preparation of alpha-aminoketone salts CIBA-GEIGY CORPORATION (US) 1994-06-21 — — US disclosed
EP-0322236-B1 Catalytic process for preparing optically active threonine TAKASAGO PERFUMERY CO LTD (JP) 1994-05-04 — — EP disclosed
US-4906773-A Process for preparing optically active threonine TAKASAGO INTERNATIONAL CORPORATION (JP) 1990-03-06 — — US disclosed
EP-0322236-A2 Catalytic process for preparing optically active threonine Takasago International Corporation (JP) 1989-06-28 — — EP disclosed
US-4593118-A 2-amido-3-aminocarboxylic acid esters and process of preparation thereof ETHYL CORPORATION (US) 1986-06-03 — — US disclosed
US-4061650-A 5-Trihalogenomethyl-4,5-dihyro-oxazole-4-carboxylic acid esters TANABE SEIYAKU CO., LTD. (JA) 1977-12-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240025856-A1 1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AS INHIBITORS OF THE YAP/TAZ-TEAD ACTIVATION FOR TREATING CANCER YAP1, TEAD2, TEAD1 LMNA 1599/4885ALDH1A1 1569/4885HSD17B10 2446/4885
US-20200407339-A1 PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF PTGER1, LOXL1, COL1A1 LMNA 907/4885ALDH1A1 421/4885HSD17B10 419/4885
US-20180339993-A1 AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS TRPM8, TRPM7, TRPM6 LMNA 3094/4885ALDH1A1 2089/4885HSD17B10 3646/4885
US-11964960-B2 Pyridinone- and pyridazinone-based compounds and uses thereof PTGER1, LOXL1, COL1A1 LMNA 907/4885ALDH1A1 421/4885HSD17B10 419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.