Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | ME2 | P23368 | 1/20 | 0.31 |
| ▸ | ME1 | P48163 | 1/20 | 0.31 |
| ▸ | ME3 | Q16798 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401641 | 0.87 | KMT2A (0.34) | KDM4EALDH1A1 | |
| SCHEMBL9648247 | 0.78 | ALDH1A1 (0.37) | HMGB1CXCL12POLBGPR35KDM4E | |
| SCHEMBL9647078 | 0.70 | ALDH1A1 (0.38) | PTPN1HMGB1CXCL12AKR1C2AKR1C1 | |
| SCHEMBL9645373 | 0.69 | NNMT (0.32) | — | |
| SCHEMBL18339051 | 0.68 | AKR1C3 (0.53) | PTPN1HMGB1CXCL12GPR35AKR1C4 | |
| SCHEMBL10401598 | 0.68 | NR4A2 (0.34) | KDM4EHSD17B10TSHRALDH1A1HPGD | |
| SCHEMBL2102413 | 0.67 | — | — | |
| SCHEMBL9518487 | 0.67 | HMGB1 (0.48) | PTPN1HMGB1CXCL12KDM4EHSD17B10 | |
| SCHEMBL9647590 | 0.67 | KLKB1 (0.61) | PTPN1KDM4EHSD17B10PTPN2PTPN6 | |
| Bromide SCHEMBL10402341 | 0.67 | NR4A2 (0.33) | KDM4EHSD17B10TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341231-B1 | SUBSTITUTED 1-(1H-IMIDAZOL-4-YL)ALKYL BENZAMIDES | U C B, S.A. (BE) | 1992-11-19 | — | — | EP | disclosed |
| EP-0341231-A1 | Substituted 1-(1H-imidazol-4-yl)alkyl benzamides | U C B, S.A. (BE) | 1989-11-08 | — | — | EP | disclosed |