Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.48 |
| ▸ | FABP6 | P51161 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667358 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665328 | 0.87 | ALDH1A1 (0.55) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665274 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665335 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665317 | 0.79 | RAB9A (0.44) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665296 | 0.78 | RAB9A (0.62) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL11277575 | 0.74 | NPSR1 (0.72) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL4065084 | 0.73 | ABL1 (0.64) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL9665262 | 0.73 | RAB9A (0.46) | SMN1; SMN2POLBALDH1A1HPGDRAB9A | |
| SCHEMBL12909208 | 0.71 | ALDH1A1 (1.00) | SMN1; SMN2POLBALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234980-B1 | 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-16 | — | — | EP | claimed |
| EP-0234980-A1 | 2-Benzimidazolylalkylthio (or sulfinyl or sulfonyl) derivatives, their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-09-02 | — | — | EP | claimed |