Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9675102 | 0.91 | CYP1A2 (0.34) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL9675417 | 0.76 | SMN1; SMN2 (0.41) | PPM1BPTPN1PPP1CC | |
| SCHEMBL5203788 | 0.76 | LMNA (0.37) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL5203793 | 0.76 | LMNA (0.37) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL5203785 | 0.76 | LMNA (0.37) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL10568510 | 0.74 | PPM1B (0.38) | PPM1BPTPN1PPP1CC | |
| SCHEMBL26694795 | 0.67 | MAPT (0.36) | CYP2C9CYP2C19PPM1BPTPN1PPP1CC | |
| SCHEMBL7331670 | 0.64 | GABRP (0.31) | TSHR | |
| SCHEMBL11589709 | 0.63 | ATM (0.41) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 | |
| SCHEMBL17723437 | 0.63 | CHRNB2 (0.35) | CYP1A2HIF1ACYP2C9TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275092-B1 | PROCESS FOR PREPARING (+)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1,7-DICARBOXYLATES | SYNTEX (U.S.A.) INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| US-4874872-A | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-17 | — | — | US | disclosed |
| US-4849526-A | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0275092-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1988-07-20 | — | — | EP | disclosed |