Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.53 |
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.53 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.51 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.51 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.51 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.51 |
| ▸ | DRD1 known ✓ | P21728 | 4/20 | 0.51 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.51 |
| ▸ | HTR2B known ✓ | P41595 | 3/20 | 0.51 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.51 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.51 |
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.51 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.51 |
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.51 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.51 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9677289 | 1.00 | LMNA (0.54) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9676172 | 0.95 | DRD2 (0.55) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9677919 | 0.90 | DRD2 (0.61) | LMNAMAPK1MEN1KMT2AKDM4E | |
| Fumaric Acid SCHEMBL11746586 | 0.89 | CYP2D6 (0.57) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9678658 | 0.89 | DRD2 (0.55) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9677473 | 0.89 | HRH1 (0.58) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9678247 | 0.87 | DRD2 (0.54) | LMNAMAPK1MEN1KMT2AKDM4E | |
| SCHEMBL9676477 | 0.87 | DRD2 (0.65) | LMNAMAPK1MEN1KMT2AKDM4E | |
| Duoperone SCHEMBL121486 | 0.87 | FPR2 (0.64) | LMNAMAPK1MEN1KMT2AKDM4E | |
| Duoperone SCHEMBL121485 | 0.87 | FPR2 (0.64) | LMNAMAPK1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290985-B1 | 1-[n-(2-Alkylthio-10H-phenothiazin-10-yl)alkyl]-4-benzoylpiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-08 | — | — | EP | disclosed |
| US-4812456-A | TREATMENT OF PAIN AND PSYCHOSIS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-03-14 | — | — | US | disclosed |
| EP-0290985-A1 | 1-[n-(2-Alkylthio-10H-phenothiazin-10-yl)alkyl]-4-benzoylpiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-11-17 | — | — | EP | disclosed |