Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681952 | 0.88 | LMNA (0.45) | HTR2AHTR1AHTR2CMAPTDRD2 | |
| SCHEMBL9682466 | 0.87 | DRD3 (0.47) | DRD4HTR2AHTR7HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL9680782 | 0.87 | LMNA (0.44) | HTR2AHTR1AHTR2CMAPTDRD2 | |
| SCHEMBL9763384 | 0.85 | KHK (0.48) | DRD4GRM2HTR2AHTR7HTR6 | |
| SCHEMBL9680665 | 0.83 | MAPK1 (0.46) | SLC6A2SLC6A4DRD4GRM2HTR7 | |
| SCHEMBL9683244 | 0.83 | SIGMAR1 (0.54) | SLC6A2SLC6A4DRD4GRM2NPSR1 | |
| Hydrochloric Acid SCHEMBL9681380 | 0.82 | SIGMAR1 (0.53) | SLC6A2SLC6A4DRD4GRM2NPSR1 | |
| SCHEMBL9680624 | 0.82 | CYP1A2 (0.46) | DRD4GRM2HTR1AHTR2CMAPT | |
| SCHEMBL9682489 | 0.79 | HTR6 (0.47) | HTR6NPSR1HTR1AHTR2CMAPT | |
| Hydrochloric Acid SCHEMBL9680573 | 0.78 | HTR6 (0.46) | HTR6NPSR1HTR1AHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | claimed |
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |
| EP-0297923-A1 | Benzodioxane prostacyclin analogues, their preparation and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |