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SCHEMBL9681008

SCHEMBL9681008

CCCCC(=O)NC(Cc1ccccc1)C(=O)Nc1c(C(C)C)cccc1C(C)C

nearest known ligand 0.59

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PSMB5 P28074 4/20 0.59
▸ SOAT2 O75908 1/20 0.54
▸ SOAT1 P35610 1/20 0.54
▸ CTSB P07858 1/20 0.53
▸ FAAH O00519 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9678920 0.90 SOAT2 (0.53) PSMB5SOAT2SOAT1
SCHEMBL9679174 0.87 SOAT2 (0.47) PSMB5SOAT2SOAT1
SCHEMBL9679311 0.84 SOAT2 (0.59) SOAT2SOAT1
SCHEMBL9679315 0.84 SOAT2 (0.59) SOAT2SOAT1
SCHEMBL9679677 0.83 SOAT2 (0.57) SOAT2SOAT1
SCHEMBL9680770 0.81 LMNA (0.62) PSMB5SOAT2SOAT1CTSB
SCHEMBL9680183 0.79 ANPEP (0.63) PSMB5SOAT2SOAT1
SCHEMBL9681111 0.79 SOAT2 (0.53) SOAT2SOAT1
SCHEMBL2565532 0.79 FAAH (0.73) PSMB5CTSBFAAH
SCHEMBL9716668 0.79 FAAH (0.73) PSMB5CTSBFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0415413-A1 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-03-06 — — EP claimed
US-5153226-A Administering as anticholesterol agents, for atherosclerosis WARNER-LAMBERT COMPANY (US) 1992-10-06 — — US disclosed
EP-0415413-A1 Acat inhibitors WARNER-LAMBERT COMPANY (US) 1991-03-06 — — EP disclosed