Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846230 | 0.86 | BTK (0.41) | MAPTKDM4EALDH1A1GAAHIF1A | |
| SCHEMBL9681915 | 0.85 | PDE10A (0.40) | MAPTKDM4EALDH1A1GAAHIF1A | |
| SCHEMBL9681299 | 0.83 | MAPT (0.35) | MAPTKDM4EALDH1A1GAAHIF1A | |
| SCHEMBL9681421 | 0.82 | MAPT (0.37) | MAPTKDM4EALDH1A1GAAHIF1A | |
| SCHEMBL9681437 | 0.78 | NPSR1 (0.34) | MAPTKDM4EGAAAPAF1RECQL | |
| SCHEMBL9682726 | 0.75 | RAB9A (0.39) | MAPTKDM4EGAAHIF1ASMN1; SMN2 | |
| SCHEMBL9681773 | 0.73 | MAPT (0.38) | MAPTKDM4EALDH1A1GAAHIF1A | |
| SCHEMBL10919184 | 0.73 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1GAABTK | |
| SCHEMBL9680853 | 0.73 | MAPT (0.38) | MAPTKDM4EALDH1A1GAAAPAF1 | |
| SCHEMBL9846283 | 0.72 | MAPT (0.35) | MAPTKDM4EALDH1A1GAAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | claimed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |