Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 known ✓ | P52333 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017854 | 0.89 | CACNA1B (0.34) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL9017858 | 0.89 | CACNA1B (0.34) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| Fumaric Acid SCHEMBL9017938 | 0.82 | BCHE (0.31) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| Maleic Acid SCHEMBL9017934 | 0.82 | BCHE (0.31) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| Maleic Acid SCHEMBL8572325 | 0.79 | TRPM8 (0.36) | NPC1ALDH1A1RAB9ASMN1; SMN2MAPK1 | |
| Dimethylcarbate SCHEMBL9679433 | 0.79 | ALDH1A1 (0.37) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| Dimethylcarbate SCHEMBL9679440 | 0.79 | ALDH1A1 (0.37) | MEN1NPC1ALDH1A1RAB9AKMT2A | |
| SCHEMBL9017918 | 0.76 | BCHE (0.34) | ALDH1A1MAPK1PRMT3LCKJAK3 | |
| Dimethylcarbate SCHEMBL9681075 | 0.74 | HTT (0.34) | ALDH1A1SMN1; SMN2PRMT3 | |
| Dimethylcarbate SCHEMBL9679397 | 0.74 | HTT (0.34) | ALDH1A1SMN1; SMN2PRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |