Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634283 | 0.84 | ALDH1A1 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC11 | |
| SCHEMBL11076358 | 0.83 | HDAC3 (0.45) | HDAC1HDAC3HDAC2HDAC8HDAC11 | |
| SCHEMBL10384783 | 0.81 | HDAC1 (0.48) | HDAC1HDAC3HDAC2HDAC8HDAC11 | |
| SCHEMBL8899426 | 0.79 | THRA (0.47) | HDAC11ALDH1A1MAPTCNR2MEN1 | |
| SCHEMBL58499 | 0.77 | KMT2A (0.51) | ALDH1A1MAPTHPGDLMNARAB9A | |
| SCHEMBL13310000 | 0.76 | EGFR (0.39) | HDAC1HDAC3HDAC2HDAC8ALDH1A1 | |
| SCHEMBL9679522 | 0.74 | ALDH1A1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC11 | |
| SCHEMBL4812459 | 0.74 | RAB9A (0.47) | HDAC1ALDH1A1MAPTHPGDLMNA | |
| SCHEMBL9679885 | 0.74 | ALDH1A1 (0.47) | HDAC1HDAC3HDAC2HDAC8HDAC11 | |
| SCHEMBL4423433 | 0.73 | MLYCD (0.34) | HDAC8ALDH1A1HPGDHSD17B10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145885-A | Morpholine compound, binders | CIBA-GEIGY CORPORATION (US) | 1992-09-08 | — | — | US | disclosed |
| US-4992547-A | Aminoaryl ketone photoinitiators | CIBA-GEIGY CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |