Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699186 | 0.77 | TP53 (0.54) | CYP2D6CYP2C19CYP2C9LMNASMN1; SMN2 | |
| SCHEMBL9682402 | 0.70 | CYP2D6 (0.45) | CYP2D6CYP2C19TSHRHIF1ACYP2C9 | |
| SCHEMBL10337098 | 0.68 | TSHR (0.53) | CYP2D6CYP2C19TSHRHIF1ACYP2C9 | |
| SCHEMBL2949433 | 0.67 | SIGMAR1 (0.51) | CYP2D6CYP2C19TSHRHIF1ACYP2C9 | |
| SCHEMBL10734461 | 0.67 | KDM4E (0.42) | CYP2D6CYP2C19TSHRHIF1ALMNA | |
| SCHEMBL9682037 | 0.67 | RXFP1 (0.44) | LMNAMEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL7015305 | 0.66 | MEN1 (0.52) | TSHRLMNAHSP90AA1HSP90B1SMN1; SMN2 | |
| SCHEMBL9700220 | 0.66 | MAPT (0.56) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL9978726 | 0.66 | CYP3A4 (0.61) | CYP2D6CYP2C19TSHRCYP2C9CYP3A4 | |
| SCHEMBL1514051 | 0.65 | KMT2A (0.46) | HIF1AKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |