Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699191 | 0.77 | PTGDR2 (0.66) | CYP2D6CYP2C19KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9682400 | 0.70 | CYP2D6 (0.48) | CYP2D6TSHRCYP2C19HIF1AKMT2A | |
| SCHEMBL6499497 | 0.70 | SMN1; SMN2 (0.42) | KMT2ALMNASMN1; SMN2MEN1PTGDR2 | |
| SCHEMBL901696 | 0.69 | CYP4F2 (0.53) | TSHRKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL5107205 | 0.69 | LMNA (0.44) | TSHRCYP2C19KMT2ALMNAALDH1A1 | |
| SCHEMBL11615589 | 0.68 | HTT (0.57) | CYP2D6CYP2C19KMT2AALDH1A1KDM4E | |
| SCHEMBL7012021 | 0.68 | MAPT (0.45) | KMT2ALMNASMN1; SMN2MEN1PTGDR2 | |
| SCHEMBL2174737 | 0.68 | LMNA (0.46) | TSHRKMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL9682042 | 0.68 | PTGDR2 (0.53) | ALDH1A1PTGDR2 | |
| SCHEMBL9700228 | 0.67 | ALDH1A1 (0.60) | LMNAALDH1A1KDM4EPTGDR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |