Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 7/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680361 | 0.86 | KDM4E (0.36) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9680894 | 0.82 | RARA (0.33) | MALT1 | |
| SCHEMBL9681489 | 0.82 | ALDH1A1 (0.41) | ABCB1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9682156 | 0.80 | ALDH1A1 (0.38) | CASP3MALT1 | |
| SCHEMBL9682834 | 0.78 | PDPK1 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9525977 | 0.77 | OPRD1 (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9680331 | 0.77 | RARA (0.40) | CASP3LMNA | |
| SCHEMBL8195282 | 0.75 | OPRD1 (0.44) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9523959 | 0.75 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9527583 | 0.75 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |