Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 19/20 | 0.63 |
| ▸ | CA1 | P00915 | 12/20 | 0.63 |
| ▸ | CA12 | O43570 | 9/20 | 0.63 |
| ▸ | CA4 | P22748 | 7/20 | 0.63 |
| ▸ | CA9 | Q16790 | 7/20 | 0.60 |
| ▸ | CA7 | P43166 | 5/20 | 0.60 |
| ▸ | CA6 | P23280 | 4/20 | 0.60 |
| ▸ | CA5A | P35218 | 4/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.60 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970472 | 0.81 | MMP9 (0.51) | CA2CA1CA12CA4CA9 | |
| SCHEMBL3368753 | 0.81 | CA2 (0.63) | CA2CA1CA12CA4CA9 | |
| SCHEMBL5635594 | 0.80 | CA2 (0.59) | CA2CA1CA12CA4CA9 | |
| SCHEMBL23632132 | 0.79 | PSIP1 (0.53) | CA2CA1CA12CA4SMN1; SMN2 | |
| SCHEMBL8764230 | 0.78 | MEN1 (0.64) | CA2CA1CA12CA4 | |
| Hydrochloric Acid SCHEMBL27515376 | 0.76 | CA2 (0.92) | CA2CA1CA12CA4CA9 | |
| SCHEMBL142107 | 0.75 | CA2 (1.00) | CA2CA1CA12CA4CA9 | |
| SCHEMBL11730795 | 0.75 | CA2 (0.69) | CA2CA1CA12CA4CA9 | |
| SCHEMBL1804221 | 0.75 | CA2 (0.69) | CA2CA1CA12CA4CA9 | |
| SCHEMBL429778 | 0.74 | CA2 (1.00) | CA2CA1CA12CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-5166218-A | Antilipemic agents or antiglycemic agents | HOFFMANN-LA ROCHE INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5064863-A | Catabolic activity, obesity, diabetes | HOFFMANN-LA ROCHE INC. (US) | 1991-11-12 | — | — | US | disclosed |
| EP-0140243-B1 | PHENOXYPROPANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-11-09 | — | — | EP | disclosed |
| US-4652679-A | Aziridine and phenethanolamine derivatives having antiobesity and anti-hyperglycaemic acitivity | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4585796-A | HYPOGLYCEMIC, ANTI-OBESITY | HOFFMANN-LA ROCHE INC. (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0101069-B1 | PHENETHANOL AMINES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-04-23 | — | — | EP | disclosed |
| EP-0140243-A2 | Phenoxypropanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-05-08 | — | — | EP | disclosed |
| EP-0101069-A1 | Phenethanol amines | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
| EP-0094595-A1 | Aziridine and phenylethanol amine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-11-23 | — | — | EP | disclosed |