SCHEMBL9685852

SCHEMBL9685852

CC(NC(=O)N(C)O)c1cc2ccccc2o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.49
LMNA P02545 1/20 0.49
THRB P10828 1/20 0.49
MAOB P27338 3/20 0.47
MAOA P21397 1/20 0.47
POLB P06746 2/20 0.46
HPGD P15428 2/20 0.44
MAPT P10636 1/20 0.44
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HSD17B10 Q99714 1/20 0.44
CYP2D6 P10635 1/20 0.44
HIF1A Q16665 1/20 0.44
TAS1R3 Q7RTX0 1/20 0.44
TAS1R1 Q7RTX1 1/20 0.44
TP53 P04637 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301099 0.82 ALDH1A1 (0.54) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL4499439 0.82 ALDH1A1 (0.54) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL9684715 0.79 ALDH1A1 (0.51) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL13601005 0.76 ALDH1A1 (0.48) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL6814826 0.76 ALDH1A1 (0.43) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL28657395 0.75 MAOB (0.48) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL10480322 0.74 ALOX5 (0.48) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL10379916 0.74 MMP9 (0.62) MEN1KMT2A
SCHEMBL178528 0.73 CYP2D6 (0.50) ALDH1A1LMNATHRBMAOBMAOA
SCHEMBL10480329 0.72 ALOX5 (0.49) ALDH1A1LMNATHRBMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1990008545-A1 LIPOXYGENASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 1990-08-09 WO claimed
US-5175183-A Antiinflammatory agents, respiratory system disorders ABBOTT LABORATORIES (US) 1992-12-29 US disclosed
WO-1990008545-A1 LIPOXYGENASE INHIBITING COMPOUNDS ABBOTT LABORATORIES (US) 1990-08-09 WO disclosed