Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683960 | 0.83 | GRK6 (0.49) | KEAP1NPC1ALDH1A1MAPTLMNA | |
| SCHEMBL9685976 | 0.81 | MAPT (0.45) | SMN1; SMN2NPC1ALDH1A1MAPTLMNA | |
| SCHEMBL9684465 | 0.81 | MAPT (0.51) | SMN1; SMN2NPC1ALDH1A1MAPTLMNA | |
| SCHEMBL9423239 | 0.74 | MAPT (0.38) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9685886 | 0.71 | CDC25B (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9684783 | 0.71 | MAPT (0.37) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9684787 | 0.71 | SOAT1 (0.39) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9684529 | 0.71 | ALDH1A1 (0.40) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL9685902 | 0.68 | S100A4 (0.42) | KEAP1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL9683947 | 0.67 | S100A4 (0.41) | KEAP1SMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5144028-A | Antibiotics | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0469844-A1 | 2-(9-fluorenonyl)-carbapenem | MERCK & CO. INC. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5025007-A | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |