Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685976 | 0.83 | MAPT (0.45) | MAPTNPC1ALDH1A1LMNAKDM4E | |
| SCHEMBL9683960 | 0.83 | GRK6 (0.49) | MAPTNPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL9685946 | 0.81 | KEAP1 (0.51) | MAPTNPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL9684473 | 0.80 | MAPT (0.54) | MAPTMITFNPC1ALDH1A1LMNA | |
| SCHEMBL21840821 | 0.77 | NPC1 (0.71) | MAPTMITFNPC1ALDH1A1LMNA | |
| SCHEMBL9684734 | 0.75 | RAB9A (0.51) | MAPTNPC1ALDH1A1LMNAKMT2A | |
| SCHEMBL8757428 | 0.74 | MAPT (0.69) | MAPTMITFNPC1ALDH1A1LMNA | |
| SCHEMBL9423239 | 0.74 | MAPT (0.38) | MAPTNPC1ALDH1A1LMNAMEN1 | |
| SCHEMBL9423198 | 0.73 | TTR (0.55) | MAPTMITFNPC1ALDH1A1LMNA | |
| SCHEMBL69292 | 0.72 | MAPT (0.61) | MAPTMITFNPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5144028-A | Antibiotics | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0469844-A1 | 2-(9-fluorenonyl)-carbapenem | MERCK & CO. INC. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5025007-A | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |