SCHEMBL9686706

SCHEMBL9686706

CC(C)C(c1cccc(Br)c1)C(Cl)(Cl)Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.39
TDO2 P48775 1/20 0.39
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
SLC6A2 P23975 3/20 0.38
SLC6A4 P31645 3/20 0.38
SLC6A3 Q01959 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KCNH2 Q12809 1/20 0.38
MAPK1 P28482 1/20 0.38
MBTD1 Q05BQ5 1/20 0.37
L3MBTL3 Q96JM7 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
MAOA P21397 1/20 0.34
PARP1 P09874 1/20 0.33
NPC1 O15118 1/20 0.33
CASP3 P42574 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9248072 0.79 ACHE (0.41) ALDH1A1MAPK1MEN1KMT2ATP53
SCHEMBL9687417 0.79 AOC3 (0.41) SLC6A2SLC6A4SLC6A3ALDH1A1KCNH2
SCHEMBL9688011 0.78 ADRB1 (0.53) CYP3A4SLC6A3ALDH1A1RAB9A
SCHEMBL9688924 0.78 ADRB1 (0.30)
SCHEMBL9687872 0.78 AOC3 (0.41) IDO1TDO2SLC6A2SLC6A4
SCHEMBL8097006 0.76 TAAR1 (0.40) CYP3A4CYP2D6SLC6A4ALDH1A1MEN1
SCHEMBL11546046 0.75 ALDH1A1 (0.42) IDO1TDO2CYP3A4CYP2D6SLC6A2
SCHEMBL38663914 0.74 ALDH1A1 (0.44) IDO1TDO2CYP3A4CYP2D6SLC6A2
SCHEMBL25584886 0.74 ALDH1A1 (0.44) IDO1TDO2CYP3A4CYP2D6SLC6A2
SCHEMBL11633922 0.74 ALDH1A1 (0.44) IDO1TDO2CYP3A4CYP2D6SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5136114-A PROCESS FOR THE PREPARATION OF GEMINAL DIARYLALKANES, NEW GEMINAL DIARYLALKANES AND ALK(EN)YLATED AROMATIC COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1992-08-04 US disclosed