Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972458 | 0.77 | MT-CO2 (0.49) | MT-CO2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL10971680 | 0.77 | POLB (0.44) | POLBHTTSMN1; SMN2MT-CO2ALDH1A1 | |
| SCHEMBL10975832 | 0.73 | HTR1A (0.34) | POLBSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL9382020 | 0.70 | EGFR (0.43) | POLBSMN1; SMN2MT-CO2ALDH1A1MEN1 | |
| SCHEMBL9686975 | 0.69 | MT-CO2 (0.41) | POLBHTTMT-CO2ALDH1A1MEN1 | |
| SCHEMBL8984088 | 0.68 | MT-CO2 (0.45) | POLBSMN1; SMN2MT-CO2ALDH1A1MEN1 | |
| SCHEMBL9384694 | 0.68 | EGFR (0.43) | SMN1; SMN2ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL9689388 | 0.67 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1MEN1KMT2ATP53 | |
| Hydrochloric Acid SCHEMBL9875354 | 0.67 | MT-CO2 (0.44) | POLBSMN1; SMN2MT-CO2ALDH1A1MEN1 | |
| SCHEMBL9876109 | 0.67 | MT-CO2 (0.41) | POLBSMN1; SMN2MT-CO2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |