Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9688696 | 0.98 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1HPGDTERT | |
| Hydrochloric Acid SCHEMBL9688707 | 0.98 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1HPGDTERT | |
| SCHEMBL9687575 | 0.93 | MTNR1A (0.53) | MTNR1AMTNR1BALDH1A1HPGDTERT | |
| SCHEMBL9687679 | 0.87 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1HPGDTERT | |
| SCHEMBL9687600 | 0.86 | MTNR1A (0.46) | MTNR1AMTNR1BCYP2D6 | |
| Hydrochloric Acid SCHEMBL9688642 | 0.85 | MTNR1A (0.45) | MTNR1AMTNR1BCYP2D6 | |
| SCHEMBL9687538 | 0.83 | MTNR1A (0.57) | MTNR1AMTNR1BALDH1A1HPGD | |
| SCHEMBL10474646 | 0.83 | MTNR1A (0.62) | MTNR1AMTNR1BALDH1A1HPGDTERT | |
| SCHEMBL10377819 | 0.80 | HTR6 (0.41) | MTNR1AMTNR1BHTR6 | |
| SCHEMBL9689411 | 0.80 | NPC1 (0.45) | MTNR1AMTNR1BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279125-B1 | TETRAHYDROPYRIDO(1,2-A)INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1992-04-29 | — | — | EP | claimed |
| EP-0279125-A1 | Tetrahydropyrido(1,2-a)indole derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-08-24 | — | — | EP | claimed |