Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688515 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL9690025 | 0.75 | PPARA (0.42) | ALDH1A1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL9689963 | 0.74 | HDAC3 (0.43) | ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL9688900 | 0.73 | KDM4E (0.41) | ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL9689940 | 0.64 | TDP1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10L3MBTL1 | |
| SCHEMBL11359304 | 0.61 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL28711075 | 0.61 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDL3MBTL1LMNA | |
| SCHEMBL9688521 | 0.61 | SIGMAR1 (0.38) | ALDH1A1KDM4EHPGDLMNAMAPT | |
| SCHEMBL9689439 | 0.61 | KDM4E (0.45) | ALDH1A1KDM4EHPGDL3MBTL1MAPT | |
| SCHEMBL9689398 | 0.60 | TDP1 (0.41) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |