SCHEMBL9688747

SCHEMBL9688747

COc1ccc(CCNC(=O)C(F)(F)F)c2c(=O)[nH][nH]c12

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.51
MTNR1A P48039 4/20 0.46
HSD17B10 Q99714 3/20 0.46
TP53 P04637 1/20 0.46
MTNR1B P49286 3/20 0.44
KDM4E B2RXH2 3/20 0.44
TSHR P16473 1/20 0.44
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C19 P33261 2/20 0.40
NQO2 P16083 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9688803 0.80 MTNR1A (0.44) ALDH1A1MTNR1AHSD17B10TP53MTNR1B
SCHEMBL7272227 0.78 ALDH1A1 (0.55) ALDH1A1MTNR1AHSD17B10TP53MTNR1B
SCHEMBL9689449 0.74 MTNR1A (0.43) ALDH1A1MTNR1AMTNR1BNQO2
SCHEMBL9689688 0.74 HTR2A (0.44) KDM4E
SCHEMBL9688089 0.74 MTNR1A (0.45) ALDH1A1MTNR1AHSD17B10TP53MTNR1B
SCHEMBL5076870 0.73 MTNR1A (0.68) ALDH1A1MTNR1AMTNR1B
SCHEMBL10923763 0.73 MTNR1A (0.44) ALDH1A1MTNR1AHSD17B10TP53MTNR1B
SCHEMBL27229064 0.73 MTNR1A (0.65) MTNR1AHSD17B10MTNR1BNQO2
SCHEMBL9786035 0.72 SLC2A1 (0.47) ALDH1A1MTNR1AMTNR1BNQO2
SCHEMBL9688973 0.71 MTNR1A (0.46) ALDH1A1MTNR1AMTNR1BCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0189473-B1 NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS SCHERING AKTIENGESELLSCHAFT (DE) 1992-05-27 EP disclosed
US-4958026-A HYPOTENSIVE AGENTS SCHERING AKTIENGESLLSCHAFT (DE) 1990-09-18 US disclosed
EP-0189473-A1 NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. SCHERING AG (DE) 1986-08-06 EP disclosed
WO-1986001204-A1 NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS SCHERING AKTIENGESELLSCHAFT (DE) 1986-02-27 WO disclosed