Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689654 | 0.83 | HTR6 (0.41) | MAPTLMNAKMT2APOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL9689762 | 0.77 | NPC1 (0.39) | RAB9ANPC1KMT2APOLBALDH1A1 | |
| SCHEMBL9689673 | 0.74 | NPC1 (0.39) | RAB9ANPC1KMT2APOLBALDH1A1 | |
| SCHEMBL9689736 | 0.73 | BRPF1 (0.40) | KMT2APOLBRECQLALDH1A1MEN1 | |
| SCHEMBL9690274 | 0.72 | PDE10A (0.42) | KMT2APOLBMEN1CYP2C9CYP2C19 | |
| SCHEMBL9689667 | 0.72 | KDM4E (0.45) | RAB9ASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL9689617 | 0.72 | DRD2 (0.55) | SMN1; SMN2MAPTKMT2APOLBTP53 | |
| SCHEMBL9689297 | 0.72 | CBX7 (0.51) | SMN1; SMN2MAPTMAPK1KMT2APOLB | |
| SCHEMBL29723995 | 0.72 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2MAPTLMNAMAPK1 | |
| SCHEMBL9689266 | 0.70 | PRMT5 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |