Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9677412 | 0.85 | KCNH2 (0.55) | MEN1KMT2AKCNH2CYP2D6PTGS2 | |
| Hydrochloric Acid SCHEMBL9689700 | 0.82 | KCNH2 (0.54) | PDE10AKCNH2CYP2D6CYP3A4CYP2C19 | |
| SCHEMBL9690235 | 0.77 | MTNR1A (0.46) | KCNH2PTGS2HDAC3HDAC4HDAC1 | |
| SCHEMBL9676515 | 0.75 | KCNH2 (0.54) | MEN1KMT2AKCNH2CYP2D6PTGS2 | |
| SCHEMBL9689736 | 0.75 | BRPF1 (0.40) | MEN1KMT2AKCNH2PTGS2CYP1A2 | |
| SCHEMBL9447468 | 0.74 | KCNH2 (0.52) | MEN1KMT2AKCNH2CYP2D6PTGS2 | |
| SCHEMBL9689716 | 0.73 | NR3C2 (0.56) | PTGS2KDM4ENR3C2ACHE | |
| SCHEMBL9678401 | 0.73 | KCNH2 (0.52) | MEN1KMT2AKCNH2CYP2D6PTGS2 | |
| SCHEMBL9689271 | 0.72 | RAB9A (0.49) | MEN1KMT2ACYP2C19CYP2C9POLB | |
| SCHEMBL9689654 | 0.71 | HTR6 (0.41) | MEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |