Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBX7 | O95931 | 1/20 | 0.51 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689736 | 0.81 | BRPF1 (0.40) | MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL9689617 | 0.74 | DRD2 (0.55) | KMT2APOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9689667 | 0.74 | KDM4E (0.45) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9689654 | 0.73 | HTR6 (0.41) | MEN1KMT2APOLBL3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL9689762 | 0.73 | NPC1 (0.39) | MEN1KMT2APOLBL3MBTL1PKM | |
| SCHEMBL9689266 | 0.73 | PRMT5 (0.42) | — | |
| SCHEMBL9689604 | 0.72 | KCNH2 (0.40) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9689271 | 0.72 | RAB9A (0.49) | MEN1KMT2APOLBMAPTTHRB | |
| SCHEMBL22284070 | 0.71 | ALDH1A1 (0.66) | POLBL3MBTL1SIGMAR1MAPK1ALDH1A1 | |
| SCHEMBL9689716 | 0.71 | NR3C2 (0.56) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |