Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689297 | 0.81 | CBX7 (0.51) | ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9689654 | 0.78 | HTR6 (0.41) | HTR6ALDH1A1POLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9689762 | 0.76 | NPC1 (0.39) | PTGS2NR3C2ALDH1A1CYP1A2POLB | |
| SCHEMBL9690274 | 0.75 | PDE10A (0.42) | PTGS2NR3C2HDAC3HDAC4HDAC1 | |
| SCHEMBL9689617 | 0.75 | DRD2 (0.55) | PTGS2ALDH1A1HTTGRIN2BPOLB | |
| SCHEMBL9689667 | 0.75 | KDM4E (0.45) | PTGS2NR3C2HDAC3HDAC4HDAC1 | |
| SCHEMBL9689266 | 0.73 | PRMT5 (0.42) | PTGS2NR3C2GRIN2BNR1I2ADRB2 | |
| SCHEMBL9689673 | 0.73 | NPC1 (0.39) | PTGS2ALDH1A1CYP1A2POLBMEN1 | |
| SCHEMBL9689271 | 0.73 | RAB9A (0.49) | ALDH1A1HTTHPGDRECQLPOLB | |
| SCHEMBL9690259 | 0.73 | KCNH2 (0.41) | PTGS2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |