Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9689836 | 0.83 | NPSR1 (0.42) | KMT2AHPGDTSHRALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL9689762 | 0.69 | NPC1 (0.39) | KMT2AALDH1A1L3MBTL1RAB9AMEN1 | |
| SCHEMBL9689673 | 0.68 | NPC1 (0.39) | KMT2AALDH1A1L3MBTL1RAB9AMEN1 | |
| SCHEMBL9677404 | 0.66 | KCNH2 (0.43) | KMT2AHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL9689271 | 0.65 | RAB9A (0.49) | KMT2AHPGDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9689654 | 0.65 | HTR6 (0.41) | KMT2AALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL12862543 | 0.65 | LMNA (0.59) | KMT2ATSHRNPSR1L3MBTL1LMNA | |
| SCHEMBL9689716 | 0.64 | NR3C2 (0.56) | HPGDALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6885992 | 0.62 | LMNA (0.77) | KMT2ATSHRNPSR1LMNASMN1; SMN2 | |
| SCHEMBL9689297 | 0.62 | CBX7 (0.51) | KMT2AALDH1A1L3MBTL1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114952-A | Side effect reduction | PFIZER INC. (US) | 1992-05-19 | — | — | US | disclosed |
| US-4990509-A | Sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4863948-A | Isoindolinone sulfonamide anti-arrhythmic agents | PFIZER, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0242173-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1987-10-21 | — | — | EP | disclosed |