Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789635 | 0.85 | KDM4E (0.58) | PKMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9690862 | 0.82 | ALDH1A1 (0.54) | PKMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10502956 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL10502995 | 0.80 | TSHR (0.47) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL10502213 | 0.80 | GAA (0.40) | ALDH1A1KDM4EHSD17B10TSHRLMNA | |
| SCHEMBL11035332 | 0.80 | DHFR (0.44) | PKMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10683747 | 0.79 | ALDH1A1 (0.44) | PKMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11001264 | 0.79 | CYP2C9 (0.49) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL10503699 | 0.78 | CACNA1F (0.41) | TP53 | |
| SCHEMBL10746130 | 0.78 | ACHE (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234516-B1 | 1,6-NAPHTHYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINE CONTAINING THEM FOR THE TREATMENT OF VASCULAR DISEASES | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1992-04-29 | — | — | EP | disclosed |
| EP-0133530-B1 | 1,6-NAPHTHYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |
| EP-0234516-A1 | 1,6-Naphthyridine derivatives, process for their preparation and medicine containing them for the treatment of vascular diseases | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1987-09-02 | — | — | EP | disclosed |