Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664963 | 0.86 | SMN1; SMN2 (0.50) | RXFP1MAPTTHRBALDH1A1KDM4E | |
| SCHEMBL9689145 | 0.83 | TP53 (0.35) | RXFP1MAPTALDH1A1KDM4ETP53 | |
| SCHEMBL27438823 | 0.82 | HRH3 (0.38) | RXFP1HPGDSMN1; SMN2APAF1RECQL | |
| SCHEMBL9691174 | 0.81 | CYP17A1 (0.49) | MAPTALDH1A1MAPK1GABRA1GABRG2 | |
| SCHEMBL9690979 | 0.80 | MAPT (0.43) | RXFP1MAPTTHRBALDH1A1KDM4E | |
| SCHEMBL9691041 | 0.78 | RAB9A (0.36) | MAPTALDH1A1KDM4ETP53POLB | |
| SCHEMBL9690785 | 0.78 | DGAT1 (0.46) | MAPTALDH1A1MAPK1GABRA1GABRG2 | |
| SCHEMBL24121997 | 0.75 | RXFP1 (0.38) | RXFP1MAPK1GABRA1GABRG2GABRB3 | |
| SCHEMBL4296654 | 0.72 | NOS3 (0.33) | — | |
| SCHEMBL9690712 | 0.70 | MAPT (0.43) | MAPTALDH1A1KDM4EGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483027-A2 | Triazolopyridazines, methods for their preparation, their use as herbicides and intermediates | RHONE-POULENC AGROCHIMIE (FR) | 1992-04-29 | — | — | EP | disclosed |