SCHEMBL9692870

SCHEMBL9692870

COC(=O)CCNC1Cc2ccccc2OC1(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.36
NOTUM Q6P988 1/20 0.36
CNR1 P21554 1/20 0.36
CNR2 P34972 1/20 0.36
CA12 O43570 2/20 0.35
CA7 P43166 2/20 0.35
CA14 Q9ULX7 2/20 0.35
CA9 Q16790 1/20 0.35
TP53 P04637 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC11 Q96DB2 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HDAC9 Q9UKV0 1/20 0.34
HDAC5 Q9UQL6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9692382 0.82 SMN1; SMN2 (0.37) SMN1; SMN2NOTUMCNR1CNR2CA12
SCHEMBL9691985 0.81 LTA4H (0.37) SMN1; SMN2NOTUMCNR1CNR2CA12
Hydrochloric Acid SCHEMBL9692609 0.80 LTA4H (0.37) SMN1; SMN2NOTUMCNR1CNR2CA12
SCHEMBL9692884 0.75 MEN1 (0.35) SMN1; SMN2NOTUMCNR1CNR2MALT1
SCHEMBL24651034 0.74 GRIN2B (0.50) NOTUMCA12CA7CA14CA9
SCHEMBL30526398 0.71 MAOA (0.38) TP53HIF1A
SCHEMBL9692800 0.70 MALT1 (0.53) TP53HDAC1MALT1
SCHEMBL9692745 0.68 SIGMAR1 (0.42) SMN1; SMN2
SCHEMBL9691921 0.68 HTT (0.35) SMN1; SMN2HDAC3HDAC4HDAC1HDAC7
SCHEMBL9458737 0.68 MALT1 (0.51) TP53HDAC1MALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0322361-A2 Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds CIBA-GEIGY AG (CH) 1989-06-28 EP claimed
US-5112855-A Nootropic Agents CIBA-GEIGY CORPORATION (US) 1992-05-12 US disclosed
US-4957928-A NOOTROPIC AGENTS, COGNITION ACTIVATORS CIBA-GEIGY CORPORATION (US) 1990-09-18 US disclosed
EP-0322361-A2 Hydrogenated 1-benzooxacycloalkyl pyridine-carboxylic-acid compounds CIBA-GEIGY AG (CH) 1989-06-28 EP disclosed