Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696229 | 0.84 | KMT2A (0.43) | KMT2APTGS2PTGS1KDM4EKCNK3 | |
| SCHEMBL9697147 | 0.79 | KMT2A (0.67) | KMT2AKDM4EKCNK3ALDH1A1LMNA | |
| SCHEMBL9695099 | 0.79 | PTGS2 (0.39) | KMT2APTGS2PTGS1KCNK3ALDH1A1 | |
| SCHEMBL9696167 | 0.75 | KMT2A (0.43) | KMT2AKDM4EKCNK3ALDH1A1LMNA | |
| SCHEMBL9764130 | 0.68 | LMNA (0.34) | KMT2APTGS2KDM4EALDH1A1LMNA | |
| SCHEMBL9697139 | 0.67 | ALDH1A1 (0.41) | KMT2AKDM4EALDH1A1LMNAHTT | |
| SCHEMBL9764105 | 0.66 | MEN1 (0.39) | KMT2APTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL10335177 | 0.65 | KMT2A (0.36) | KMT2APTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL9696155 | 0.65 | KMT2A (0.35) | KMT2APTGS2PTGS1KDM4EKCNK3 | |
| SCHEMBL9764313 | 0.65 | PTGS2 (0.43) | PTGS2KDM4EALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124453-A | Treatment of corresponding aldehyde with lithium bis(tri-methylsilyl)amide | E. R. SQUIBB & SONS, INC. (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0444532-A1 | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method | E.R. SQUIBB & SONS, INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-5025000-A | Anticholesterol, antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1991-06-18 | — | — | US | disclosed |