Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31626895 | 1.00 | DGAT1 (0.37) | DGAT1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL9243513 | 0.88 | DGAT1 (0.41) | DGAT1LMNAALDH1A1HSD17B10PKM | |
| SCHEMBL13317330 | 0.84 | DGAT1 (0.38) | DGAT1LMNAALDH1A1HSD17B10PKM | |
| SCHEMBL17617204 | 0.84 | DGAT1 (0.38) | DGAT1LMNAALDH1A1HSD17B10PKM | |
| SCHEMBL769720 | 0.83 | DGAT1 (0.44) | DGAT1ALDH1A1HSD17B10KDM4EPKM | |
| SCHEMBL106266 | 0.81 | DGAT1 (0.39) | DGAT1ALDH1A1KDM4EPKMCYP4F2 | |
| SCHEMBL19906462 | 0.80 | LMNA (0.39) | DGAT1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL18937192 | 0.80 | CYP4A11 (0.44) | DGAT1CYP4F2CYP4A11TSHRTDP1 | |
| SCHEMBL20732580 | 0.80 | LMNA (0.39) | DGAT1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL27916314 | 0.80 | ALDH1A1 (0.39) | DGAT1LMNAALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841418-B1 | (3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES | HOFFMANN LA ROCHE (CH) | 2017-03-08 | — | — | EP | disclosed |
| WO-2009133264-A2 | MODIFICATION OF THE SURFACE CHEMISTRY OF MACROMOLECULAR SPECIES IN THE PRESENCE OF A CONJUGATED GUANIDINE | POLYRISE (FR) | 2009-11-05 | — | — | WO | disclosed |
| WO-1992002572-A1 | ASSOCIATIVE REACTIVE BLEND-CONTAINING COMPOSITIONS | DSM N.V. (NL) | 1992-02-20 | — | — | WO | disclosed |