Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | DRD3 | P35462 | 3/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700309 | 0.81 | NOTUM (0.38) | NOTUMAADATRIPK1GAACA2 | |
| SCHEMBL9699339 | 0.75 | NOTUM (0.39) | NOTUMDRD2DRD3RIPK1GAA | |
| SCHEMBL9699297 | 0.72 | NOTUM (0.38) | NOTUMSMN1; SMN2DRD2 | |
| SCHEMBL9699310 | 0.72 | NOTUM (0.38) | NOTUMDRD2 | |
| SCHEMBL9701449 | 0.72 | DRD2 (0.41) | NOTUMDRD2DRD3 | |
| SCHEMBL9700270 | 0.69 | CYP2A13 (0.37) | NOTUMDRD2DRD3 | |
| SCHEMBL1561549 | 0.69 | RIPK1 (0.44) | NOTUMAADATDRD2DRD3RIPK1 | |
| SCHEMBL1561550 | 0.69 | RIPK1 (0.44) | NOTUMAADATDRD2DRD3RIPK1 | |
| Hydrochloric Acid SCHEMBL19207975 | 0.68 | RIPK1 (0.43) | NOTUMAADATDRD2DRD3RIPK1 | |
| SCHEMBL9700406 | 0.66 | ADRB1 (0.38) | NOTUMDRD2DRD3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |