Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699297 | 0.89 | NOTUM (0.38) | DRD2NOTUMDRD4 | |
| SCHEMBL9699310 | 0.89 | NOTUM (0.38) | DRD2NOTUMDRD4 | |
| SCHEMBL9700270 | 0.86 | CYP2A13 (0.37) | DRD2DRD3NOTUMDRD4 | |
| SCHEMBL9700405 | 0.85 | ADRA2A (0.43) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL9728710 | 0.83 | DRD2 (0.40) | DRD2DRD3NOTUMHTR1AHTR2A | |
| SCHEMBL9700406 | 0.82 | ADRB1 (0.38) | DRD2DRD3NOTUMHTR1AHTR2A | |
| SCHEMBL9700309 | 0.79 | NOTUM (0.38) | NOTUMHTR2AHTR2CHTR6 | |
| SCHEMBL9699339 | 0.78 | NOTUM (0.39) | DRD2DRD3NOTUM | |
| SCHEMBL9699253 | 0.76 | ADRA2A (0.42) | DRD2DRD3HTR1AHTR2ADRD4 | |
| SCHEMBL9699344 | 0.73 | ADRA1A (0.42) | DRD2DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |