Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 11/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378979 | 0.87 | ADRA1A (0.38) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9700158 | 0.85 | HTR2A (0.38) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL9700368 | 0.82 | NOTUM (0.37) | ADRA1DADRA1AADRA1BCYP2D6SLC6A2 | |
| SCHEMBL9701394 | 0.81 | ADRA1A (0.36) | ADRA1DADRA1AADRA1BKDM4EADRA2A | |
| SCHEMBL9700351 | 0.80 | ADRA2A (0.41) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9701613 | 0.80 | ADRA2A (0.41) | ADRA1DADRA1AADRA1BHTR1AADRA2A | |
| SCHEMBL10471313 | 0.79 | ADRA2A (0.37) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9699337 | 0.78 | ADRA2A (0.42) | ADRA1DADRA1AADRA1BHTR1AADRA2A | |
| SCHEMBL9728617 | 0.77 | ADRA1A (0.41) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL9699287 | 0.74 | HTR7 (0.40) | ADRA1DADRA1AADRA1BHTR1ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |