Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 11/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699276 | 0.85 | ADRA2A (0.35) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9699339 | 0.84 | NOTUM (0.39) | ADRA1AADRA1DADRA1BDRD2XIAP | |
| SCHEMBL9700327 | 0.81 | ADRA1D (0.38) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9701674 | 0.81 | ADRA2A (0.42) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9699253 | 0.81 | ADRA2A (0.42) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9700405 | 0.80 | ADRA2A (0.43) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9699344 | 0.79 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9701648 | 0.76 | LMNA (0.41) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL9701645 | 0.75 | HTR2C (0.35) | DRD2 | |
| SCHEMBL10378979 | 0.71 | ADRA1A (0.38) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |