Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11139976 | 0.95 | ALDH1A1 (0.55) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL29219054 | 0.90 | ALDH1A1 (0.66) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL153386 | 0.86 | ALDH1A1 (0.76) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL9483307 | 0.86 | MAPT (0.48) | ALDH1A1LMNAALOX15MAPK1TDP1 | |
| SCHEMBL28029377 | 0.85 | HDAC8 (0.65) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL459470 | 0.84 | KMT2A (0.70) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL6284359 | 0.84 | MMP1 (0.63) | ALDH1A1HSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL585367 | 0.83 | HDAC1 (0.57) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| 1,4-Dimethoxybenzene SCHEMBL27728279 | 0.82 | NR1I2 (0.58) | TDP1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11327776 | 0.82 | HDAC1 (0.57) | ALDH1A1LMNAALOX15APEX1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108689973-A | A kind of preparation method of 2- ethyls -3- (4- hydroxy benzoyls) benzofuran | 华中科技大学 | 2018-10-23 | — | — | CN | claimed |
| US-RE50083-E1 | URAT1 inhibitor and use thereof | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2024-08-20 | — | — | US | disclosed |
| CN-117586272-A | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-111615515-B | Heterocyclic compound, preparation method and application thereof in medicine | 苏州信诺维医药科技股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| EP-3741759-B1 | IMIDAZO[1,2-A]PYRIMIDINE AND IMIDAZO[1,2-C]PYRIMIDINE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF HYPERURICEMIA AND GOUT | EVOPOINT BIOSCIENCES CO LTD (CN) | 2023-08-23 | — | — | EP | disclosed |
| EP-3741759-B1 | IMIDAZO[1,2-A]PYRIMIDINE AND IMIDAZO[1,2-C]PYRIMIDINE COMPOUNDS AND USE THEREOF IN THE TREATMENT OF HYPERURICEMIA AND GOUT | EVOPOINT BIOSCIENCES CO LTD (CN) | 2023-08-23 | — | — | EP | disclosed |
| US-11597725-B2 | URAT1 inhibitor for promoting uric acid excretion | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2023-03-07 | — | — | US | disclosed |
| US-11453674-B2 | Heterocyclic compound, preparation method and use thereof in medicine | Evopoint Biosciences Co., Ltd. (CN) | 2022-09-27 | — | — | US | disclosed |
| EP-3543240-B1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3543240-B1 | URAT1 INHIBITOR AND USE THEREOF | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| US-20180282321-A1 | COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT | JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD. (CN) | 2018-10-04 | — | — | US | disclosed |
| EP-3348557-A1 | COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd (CN) | 2018-07-18 | — | — | EP | disclosed |
| EP-3348557-A1 | COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT | Jiangsu Atom Bioscience And Pharmaceutical Co., Ltd (CN) | 2018-07-18 | — | — | EP | disclosed |
| WO-2018090921-A1 | URAT1 INHIBITOR AND USE THEREOF | 江苏新元素医药科技有限公司 | 2018-05-24 | — | — | WO | disclosed |
| WO-2017041732-A1 | COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT | 江苏新元素医药科技有限公司 | 2017-03-16 | — | — | WO | disclosed |
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597725-B2 | URAT1 inhibitor for promoting uric acid excretion | SLC10A6, SLC10A1, SLC28A1 | ALDH1A1 326/4885LMNA 3692/4885ALOX15 2596/4885 |
| US-20180282321-A1 | COMPOUND FOR TREATING OR PREVENTING HYPERURICEMIA OR GOUT | SLC10A1, SLC5A1, SLC10A6 | ALDH1A1 716/4885LMNA 2942/4885ALOX15 1010/4885 |
| US-11453674-B2 | Heterocyclic compound, preparation method and use thereof in medicine | PAH, NLRP3, CYP11B2 | ALDH1A1 1562/4885LMNA 830/4885ALOX15 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.