Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808063 | 0.88 | HTR6 (0.50) | HTR6HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL7809786 | 0.80 | HDAC3 (0.50) | HTR6HDAC3ICMTCDC25ALMNA | |
| SCHEMBL3328890 | 0.79 | HTR6 (1.00) | HTR6HDAC3 | |
| SCHEMBL9701525 | 0.77 | ALDH1A1 (0.44) | KMT2AALDH1A1CREBBPPOLBSMN1; SMN2 | |
| SCHEMBL9701519 | 0.76 | KMT2A (0.60) | HTR6HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL7815554 | 0.74 | HDAC1 (0.49) | HTR6HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL12850648 | 0.73 | HDAC6 (0.74) | HDAC3HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL9701366 | 0.73 | HTR6 (0.62) | HTR6HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL28313770 | 0.72 | HDAC1 (0.68) | HTR6HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL7811888 | 0.71 | CAMK2D (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132319-A | Antiasthmatic, antiinflammatory, antiallergen and cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1992-07-21 | — | — | US | disclosed |