Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9702854 | 0.83 | CDK4 (0.45) | PDE5ASRCAMY1A | |
| SCHEMBL9703649 | 0.82 | AMY1A (0.43) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL10852513 | 0.81 | AMY1A (0.40) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL9704539 | 0.80 | AMY1A (0.40) | PDE5AAMY1APDE3BPDE3ANPC1 | |
| SCHEMBL9702924 | 0.80 | AMY1A (0.41) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL10688023 | 0.79 | FGFR1 (0.42) | PDE5ASRCPDE3BPDE3APDE2A | |
| SCHEMBL10373752 | 0.77 | PDE3B (0.48) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL9705442 | 0.77 | KDM4E (0.41) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL9703428 | 0.77 | PDE3B (0.41) | PDE5AAMY1APDE3BPDE3APDE2A | |
| SCHEMBL10551908 | 0.75 | AMY1A (0.39) | PDE5AAMY1APDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116843-A | Anticoagulants, hypotensive agents and cardiovascular disorder | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| EP-0275888-A2 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | Roche Diagnostics GmbH (DE) | 1988-07-27 | — | — | EP | disclosed |