Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 8/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 7/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28618814 | 0.85 | ESR2 (0.56) | ESR2HDAC4HDAC2HDAC8ESR1 | |
| SCHEMBL9702964 | 0.77 | HSD17B1 (0.40) | ESR2ESR1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL27877792 | 0.72 | HSD17B1 (0.50) | ESR2ESR1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL3790386 | 0.72 | MAP4K4 (0.50) | HSD17B1HSD17B2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30439996 | 0.72 | HSD17B1 (0.50) | ESR2ESR1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL13670758 | 0.71 | MCL1 (0.46) | ESR2HDAC4HDAC2HDAC8CYP1A2 | |
| SCHEMBL3789766 | 0.71 | ALDH1A1 (0.43) | CYP3A4APPCTDSP1MEN1LMNA | |
| SCHEMBL19880343 | 0.70 | ESR1 (0.44) | ESR2ESR1HSD17B1HSD17B2CYP1A2 | |
| SCHEMBL564030 | 0.70 | CASP7 (0.50) | CYP1A2CYP3A4CTDSP1MEN1LMNA | |
| SCHEMBL565555 | 0.69 | ALDH1A1 (0.62) | HDAC4HDAC2HDAC8HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221677-B1 | P-AMINOPHENOLS, DERIVATIVES THEREOF AND USE FOR MANUFACTURE OF A MEDICAMENT | E.R. Squibb & Sons, Inc. (US) | 1992-09-09 | — | — | EP | claimed |
| US-4910208-A | Skin disorders, antiinflammatory agent | E. R. SQUIBB & SONS, INC. (US) | 1990-03-20 | — | — | US | claimed |
| EP-0221677-A2 | p-Aminophenols, derivatives thereof and use for manufacture of a medicament | E.R. Squibb & Sons, Inc. (US) | 1987-05-13 | — | — | EP | claimed |