Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | ATIC | P31939 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30517293 | 0.84 | LMNA (0.78) | LMNACYP2C9KMT2AMEN1ATIC | |
| SCHEMBL1414326 | 0.84 | LMNA (0.78) | LMNACYP2C9KMT2AMEN1ATIC | |
| SCHEMBL28007728 | 0.82 | KDM4E (0.68) | LMNAKMT2AMEN1MAPK1SMN1; SMN2 | |
| Sulfaquinoxaline SCHEMBL4435622 | 0.82 | LMNA (1.00) | LMNACYP2C9KMT2AMEN1ATIC | |
| Sulfaquinoxaline SCHEMBL93789 | 0.82 | LMNA (1.00) | LMNACYP2C9KMT2AMEN1ATIC | |
| Sulfaquinoxaline SCHEMBL29391090 | 0.82 | LMNA (1.00) | LMNACYP2C9KMT2AMEN1ATIC | |
| SCHEMBL15256346 | 0.82 | LMNA (0.74) | LMNACYP2C9KMT2AMEN1ATIC | |
| Sulfaquinoxaline SCHEMBL27961007 | 0.81 | LMNA (0.97) | LMNACYP2C9KMT2AMEN1ATIC | |
| Sulfaquinoxaline SCHEMBL301314 | 0.81 | LMNA (0.97) | LMNACYP2C9KMT2AMEN1ATIC | |
| SCHEMBL2407197 | 0.77 | L3MBTL1 (0.66) | LMNAKMT2AMEN1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215200-B1 | USE OF SULFANILAMIDO QUINOXALINES IN THE TREATMENT OF NEOPLASTIC DISEASES | MERCK & CO. INC. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-4931433-A | Method for treating certain neoplastic diseases | MERCK & CO., INC. (US) | 1990-06-05 | — | — | US | disclosed |
| EP-0215200-A2 | Use of sulfanilamido quinoxalines in the treatment of neoplastic diseases | MERCK & CO. INC. (US) | 1987-03-25 | — | — | EP | disclosed |