SCHEMBL9704031

SCHEMBL9704031

Cc1c(CBr)c(O[SiH](c2ccccc2)c2ccccc2)cc2cc(C(C)(C)C)ccc12

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9080432 0.71 NR1I2 (0.32) KIF11
SCHEMBL7313369 0.68
SCHEMBL8877133 0.66 ENPP2 (0.35) KIF11
SCHEMBL7736892 0.66
SCHEMBL3714765 0.65 LMNA (0.35)
SCHEMBL27238865 0.64 MAOB (0.41)
SCHEMBL9701313 0.64 CYP2D6 (0.35) KIF11
SCHEMBL704146 0.64 ALDH1A1 (0.43)
SCHEMBL9043924 0.63 KDM4E (0.39) KIF11
SCHEMBL177163 0.63 KIF11 (0.42) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992005153-A1 ANTIPROLIFERATIVE SUBSTITUTED NAPHTHALENE COMPOUNDS AGOURON PHARMACEUTICALS, INC. (US) 1992-04-02 WO disclosed