SCHEMBL9706162

SCHEMBL9706162

CCCC(O)C1C(CO)CC1n1cc(C=CBr)c(=O)[nH]c1=O

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TK1 P04183 4/20 0.56
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
TSHR P16473 1/20 0.49
BLM P54132 1/20 0.49
PMP22 Q01453 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
TK2 O00142 11/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706119 0.92 TK1 (0.61) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL9706093 0.89 TK1 (0.61) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL9706112 0.83 TK1 (0.47) TK1BLMTK2
SCHEMBL9706120 0.82 LMNA (0.45) TK1CYP3A4TSHRPMP22TK2
SCHEMBL9309692 0.81 TK1 (0.76) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL8798117 0.81 TK1 (0.67) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL9481617 0.81 TK1 (0.67) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL8689486 0.81 TK1 (0.67) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL9308662 0.77 TK1 (0.88) TK1CYP1A2CYP3A4TSHRBLM
SCHEMBL9706294 0.76 SLC28A1 (0.39) TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0481320-A1 Novel cyclobutane derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1992-04-22 EP disclosed