SCHEMBL9706682

SCHEMBL9706682

CC(=O)n1c2c(c(=O)n(-c3cc(C(=O)O)c(Cl)cc3F)c1=O)CCC2

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.33
EPHX2 P34913 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
HPGD P15428 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TTR P02766 1/20 0.31
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706658 0.89 EPHX2 (0.32) TSHREPHX2MEN1ALDH1A1LMNA
SCHEMBL9706554 0.87 HPGD (0.34) TSHREPHX2MEN1ALDH1A1LMNA
SCHEMBL9706504 0.86 PPOX (0.33) LMNAHPGDSMN1; SMN2
SCHEMBL10645585 0.86 HPGD (0.34) TSHREPHX2MEN1ALDH1A1LMNA
SCHEMBL9706687 0.85 HPGD (0.34) TSHREPHX2MEN1ALDH1A1LMNA
SCHEMBL9423141 0.81 TSHR (0.36) TSHRALDH1A1HPGDSMN1; SMN2
SCHEMBL9706531 0.77 MAPT (0.34) LMNAHPGDSMN1; SMN2
SCHEMBL10645580 0.77 HPGD (0.31) TSHRHPGDSMN1; SMN2
SCHEMBL10873317 0.77 RXRA (0.34) TSHRMEN1LMNAKMT2ATTR
SCHEMBL9706680 0.77 LMNA (0.37) TSHRMEN1ALDH1A1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0195346-B1 3-ARYL URACILES AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1992-06-24 EP claimed